Chloroquine and pregnancy

Discussion in 'Aralen 150 Mg' started by betec, 25-Feb-2020.

  1. Salahadin Well-Known Member

    Chloroquine and pregnancy

    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Chloroquine is a 9-aminoquinoline known since 1934. Apart from its well-known antimalarial effects, the drug has interesting biochemical properties that might be applied against some viral infections. Chloroquine exerts direct antiviral effects, inhibiting pH-dependent steps of the replication of several viruses including members of the flaviviruses, retroviruses, and coronaviruses. Its best. Chloroquine has not been formally assigned to a pregnancy category by the FDA. There are no controlled data in human pregnancies. Congenital anomalies were reported in the offspring of one woman being treated with chloroquine 250 to 500 mg daily during pregnancy for SLE; however, chloroquine has been used in the prophylaxis and treatment of malaria during pregnancy without evidence of fetal harm. Background/Purpose Chloroquine CQ and Hydroxychloroquine HCQ have been used for years during pregnancy for multiple indications malaria prevention, autoimmune disorders, etc. Recently, some countries face restrictions to prescribe these drugs during pregnancy, due to report of ocular toxicity in animal models and potential genotoxicity.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine and pregnancy

    Drug Safety in Pregnant & Nursing Women, Chloroquine Use During Pregnancy

  2. Malaria drug combined mice chloroquine 17
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  5. The CDC recommends continuing your other malaria treatment such as chloroquine throughout pregnancy until delivery to prevent harm to your unborn baby hemolytic anemia. After delivery, you may.

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    Anti-malarial drugs hydroxychloroquine, chloroquine are considered pregnancy category C drugs. While there is evidence of risk for damage to the eye and ear, if the benefits of these drugs in controlling RA symptoms are judged to outweigh the risks, they may continue to be used during pregnancy. 1,2. Tell your doctor if you have ever had vision changes while taking chloroquine phosphate, chloroquine hydrochloride Aralen HCl, or hydroxychloroquine Plaquenil. tell your doctor if you are pregnant or plan to become pregnant. If you become pregnant while using chloroquine phosphate, call your doctor. Hydroxychloroquine Pregnancy Warnings Animal studies have revealed evidence of fetal harm. Use of chloroquine and other 4-aminoquinolines in high doses and for prolonged durations has been associated with neurological disturbances and interference with hearing, balance, and vision in the fetus.

  6. amirhost Well-Known Member

    Authors: Dr Anes Yang, Clinical Researcher, Department of Dermatology, St George Hospital, University of New South Wales, Sydney, NSW, Australia; Dr Monisha Gupta, Senior Staff Specialist, Department of Dermatology, Liverpool Hospital, Sydney, NSW, Australia. It is a hydroxylated version of chloroquine, with a similar mechanism of action. Compare Chloroquine vs Plaquenil - Hydroxychloroquine MedlinePlus Drug Information Hydroxychloroquine vs Plaquenil Comparison -
  7. Teo_WtblLL XenForo Moderator

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  8. bazeta New Member

    Chloroquine Is a Zinc Ionophore - PubMed Central PMC Chloroquine is an antimalarial drug that has been used in humans for many years. In recent years, Chloroquine has been shown to inhibit autophagy and induce apoptosis in malignant cells and thus has been tested in various experimental model systems and in human clinical trials.

    Chloroquine Oral Route Proper Use - Mayo Clinic
  9. Yoshmitsu Moderator

    Prophylaxis of Malaria - PubMed Central PMC The spread of drug –resistant falciparum malaria, and the widespread reluctance to use the known anti-malaria drugs due to their side effects, led to the pursuit of new antimalaria drugs. Atovaquone-proguanil Malarone is the latest anti-malarial drug to be developed.

    Malaria Prevention –