Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Chloroquine side effect homicide Manufacturers of plaquenil Hydroxychloroquine side effects diarrhea Effects of stop taking plaquenil You may more likely to get toxic liver disease if You take OTC pain relievers way too often, over the recommended dose, or with alcohol. You already have another liver disease, like cirrhosis. Rates of transaminitis were compared to weekly alcohol consumption in RA patients taking MTX. In this study, a unit of alcohol represents 10 mL or eight grams of pure alcohol. The researchers found that, overall, increased weekly alcohol consumption was associated with an increased risk of transaminitis. Safety and efficacy of hydroxychloroquine to treat lupus and arthritis have not been established in children. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Liver disease—Use with caution. The. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Hydroxychloroquine liver toxicity alcohol Plaquenil Side Effects Common, Severe, Long Term -, RA Patients on Methotrexate and Alcohol Consumption a New Risk Study Generic for hydroxychloroquine 200 mg Aug 30, 2011 Chloroquine-induced retinal toxicity was first described in 1959 and the retinal toxic effects of hydroxychloroquine were later described in 1967 3, 4. Hydroxychloroquine has significantly less retinal toxicity and has largely replaced chloroquine as a treatment of inflammatory disease. Hydroxychloroquine Plaquenil Toxicity and Recommendations.. Hydroxychloroquine Oral Route Before Using - Mayo Clinic. Alcohol and the Liver - Alcohol Alert No. 19-1993. The risk of retinal toxicity is dependent on several factors A daily dose of hydroxychloroquine 5.0 mg/kg using the patient's body weight. Severe renal impairment. Concomitant use of tamoxifen. Duration of use 5 years. Jan 05, 2020 Hydroxychloroquine is a well tolerated medication for various rheumatologic and dermatologic conditions. Its main side effects are gastrointestinal upset, skin rash, headache, and ocular toxicity. Within the eye, hydroxychloroquine negatively impacts the cornea, ciliary body, and retina. Sep 15, 2014 Hydroxychloroquine sulfate HCQ, Plaquenil is an analogue of chloroquine CQ, an antimalarial agent, used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune disorders. Its use has been associated with severe retinal toxicity, requiring a discontinuation of therapy.