Hydroxychloroquine induced cardiomyopathy in systemic lupus erythematosus

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    Hydroxychloroquine induced cardiomyopathy in systemic lupus erythematosus


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    The correct answer is B. Add hydroxychloroquine. Hydroxychloroquine is an appropriate agent to address milder systemic manifestations of systemic lupus erythematosus SLE such as arthritis and pericarditis, and it can act as a glucocorticoid-sparing agent. All patients with SLE who can tolerate it should be taking hydroxychloroquine. Hydroxychloroquine HCQ is extensively used in the long-term treatment of systemic lupus erythematosus SLE. Although considered by clinicians to be relatively safe, serious side effects have. Sep 13, 2017 HCQ-induced cardiomyopathy is one of the rare but severe complications which could be reversible with early withdrawal of the drug. However, the exact mechanism of HCQ cardiotoxicity remains unclear and the role of heredity has not been studied due to the rare occurrence of the disease. We present a case of twin sisters who both suffered from systemic lupus erythematosus SLE and HCQ-induced cardiomyopathy presenting with decompensated heart failure HF.

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    Hydroxychloroquine induced cardiomyopathy in systemic lupus erythematosus

    Hydroxychloroquine-induced cardiomyopathy case report., Hydroxychloroquine Cardiotoxicity in Systemic Lupus.

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  4. Hydroxychloroquine, originally used as an antimalarial agent, has beneficial effects on mucocutaneous symptoms in systemic lupus erythematosus. It is also used for the skin rash of discoid lupus erythematosus. A number of rare but serious adverse reactions can occur with its use and are usually associated with long-term therapy.

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    Hydroxychloroquine HCQ is a well‐established and effective immunomodulatory therapy for systemic lupus erythematosus and other autoimmune diseases. While retinal toxicity is a well‐recognized complication, cardiotoxicity is lesser known. Hydroxychloroquine and its predecessor chloroquine are medications commonly used in the treatment of systemic lupus erythematosus, rheumatoid arthritis, and other connective tissue disorders. Hydroxychloroquine interferes with malarial metabolites, confers immunomodulatory effects, and also affects lysosomal function. Mar 27, 2007 In patients with systemic lupus erythematosus SLE, hydroxychloroquine prevents disease flares and damage accrual and facilitates the response to mycophenolate mofetil in those with renal involvement. A study was undertaken to determine whether hydroxychloroquine also exerts a protective effect on survival.

     
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