Act with chloroquine tafenoquine

Discussion in 'Canada Pharmaceuticals Online' started by WMDrakon, 04-Mar-2020.

  1. Rrrat Well-Known Member

    Act with chloroquine tafenoquine

    As with primaquine, tafenoquine can cause severe hemolytic anemia in people with G6PD deficiency. Those with partial deficiency that may be missed by qualitative testing may also be at risk for hemolysis.

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    Tafenoquine is in development as a single-dose treatment for relapse prevention in individuals with Plasmodium vivax malaria. Tafenoquine must be coadministered with a blood schizonticide, either chloroquine or artemisinin-based combination therapy ACT. Jun 16, 2016 In Indonesia, chloroquine has been replaced by artemisinin-based combination therapy i.e. ACTs due to widespread chloroquine resistance. This study will evaluate the efficacy and safety of a single dose of tafenoquine when co-administered with an ACT i.e. DHA-PQP. Tafenoquine is used in combination with another medication such as chloroquine to treat and prevent the return of malaria. Malaria is caused by infection with a parasite spread by mosquito bite.

    Tafenoquine use in people with G6PD deficiency or unknown G6PD status is contraindicated. Therefore, physicians must perform G6PD testing before prescribing tafenoquine.

    Act with chloroquine tafenoquine

    Tafenoquine Dosage Guide with Precautions -, Efficacy and Safety Study of Tafenoquine TQ Co-administered.

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  7. Single-dose tafenoquine 300 mg coadministered with chloroquine for P vivax malaria relapse prevention was more efficacious than chloroquine alone, with a similar safety profile. As a result, it has been selected for further clinical assessment in phase 3.

    • Tafenoquine plus chloroquine for the treatment and relapse..
    • Tafenoquine 150 mg tablet Kaiser Permanente.
    • Information paper mefloquine and tafenoquine.

    Radical cure” of vivax involves treatment with a drug targeting the dormant liver forms of the parasite given in combination with currently available anti-malarials like chloroquine or artemisinin-based combination therapies ACT. Chloroquine binds to heme or FP to form the FP-chloroquine complex; this complex is highly toxic to the cell and disrupts membrane function. Action of the toxic FP-chloroquine and FP results in cell lysis and ultimately parasite cell autodigestion. Tafenoquine, an 8-aminoquinoline drug related to primaquine, is only the second drug of its class to receive FDA approval. Tafenoquine kills both the liver and blood stages of the parasite, broadening its applicability for chemoprophylaxis to all species of malaria.

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