Personally, I will be taking this when Casodex begins to fail. Bicalutamide and Chloroquine study"Taken together, our data suggest that autophagy is a protective mechanism against androgen deprivation in HRPCa cells and that chloroquine could restore hormone dependence. I also note this: "The strategy is currently being tested in clinical trials, and preliminary results are promising. Plaquenil and mmr vaccine Reactions to plaquenil The safe anti-malarial drug chloroquine, an inhibitor of autophagy, dramatically increased cell death after androgen deprivation or bicalutamide treatment." This is an in vitro study, but if you were going to Africa some places they would give you Chloroquine regardless of prostate cancer. Chloroquine is an established antimalarial agent that has been recently tested in clinical trials for its anticancer activity. The favorable effect of chloroquine appears to be due to its ability to sensitize cancerous cells to chemotherapy, radiation therapy, and induce apoptosis. Autophagy and cancer. A large body of evidence suggests that the relationship between autophagy and cancer is complex.42, 43 On the one hand, autophagy appears to inhibit malignant transformation, reflecting its capability to limit the accumulation of potentially oncogenic entities like depolarized mitochondria which overproduce potentially genotoxic reactive oxygen species, ROS. The plant contains a volatile oil with a high level of thujone (see Thuja). This set of data could lead to the development of new therapeutic strategy against HRPCa."Comments and discussion would be much appreciated... The catch, though, is that it's not always possible to give patients a high enough dose of hydroxychloroquine to have an effect on their tumor cells." "Available scientific evidence does not support claims that wormwood is effective in treating cancer, the side effects of cancer treatment, or any other conditions. Chloroquine and prostate cancer Antimalarial drugs could support existing cancer., Chloroquine Is a Zinc Ionophore - PubMed Central PMC Special eye exams for people on plaquenilHonduras chloroquine sensitiveChloroquine malaria drugPlaquenil 200 mg precio argentina The Chloroquine Story in Cancer Continues. By Derek Lowe 10 February, 2016. Chloroquine’s effects on bladder cancer cell lines, it turns out, can be shut down by providing the cells with extra cholesterol, and those effects can be recapitulated by giving them statin drugs or disrupting their cholesterol synthesis pathways by RNA interference. The Chloroquine Story in Cancer Continues In the Pipeline. Chloroquine and hydroxychloroquine for cancer therapy. Prostate cancer cells at a therapeutic gunpoint of the.. Chloroquines are expected to have diverse effects on cancer progression. Inhibition of late autophagy can affect cell survival, as well as antigen processing and presentation in the immune system. Co. A preclinical study in a mouse model found that a combination of DIM 10 mg/kg and chloroquine 60 mg/kg, taken 3x/week, significantly decreased prostate cancer PC-3 tumor growth in vivo after 3 and 4 weeks of treatment. 10 The mouse prostate cancer model used was a unique one, as the researchers performed a xenograft i.e. tissue graft. In models where ER stress induced the apoptosis of colon cancer HCT116 cells and prostate cancer DU145 cells, autophagy may reduce cell vacuoles, alleviate the ER stress and protect cells from death 36–38. In the present study, the inhibition of autophagy in cholangiocarcinoma QBC939 cells by CQ significantly increased the expression of two.