Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. Discoid lupus plaquenil Hydroxychloroquine chronic fatigue Chloroquine binds to heme or FP to form the FP-chloroquine complex; this complex is highly toxic to the cell and disrupts membrane function. Action of the toxic FP-chloroquine and FP results in cell lysis and ultimately parasite cell autodigestion. In essence, the parasite cell drowns in its own metabolic products. Malaria is a protozoan infection, caused by the bite of the female Anopheles mosquito. This article reviews the various antimalarial drugs, mechanisms of action, adverse effects/toxicity, and drugs of choice. Important therapeutic aspects of individual drugs will also be covered. The exact mechanism by which chloroquine inhibits hemozoin formation is not known, but chloroquine can bind heme and this binding may prevent the heme from being incorporated into the hemozin crystal. Parasite killing is therefore a result of the accumulation of metabolic wastes ie, heme associated with the digestion of hemoglobin. The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. What is the mechanism of action of chloroquine and primaquine CHLOROQUINE PHOSPHATE, USP, Antimalarial Drugs — Quinine, Quinidine, Sulfonamides, Chloroquine and More Coming off hydroxychloroquineChloroquine diphosphate packagingPlaquenil and proceduresDiscontinuing plaquenil now have muscle spasmsPlaquenil patient assistance Primaquine About Primaquine 8-Aminoquinolone compound, Antimalarial. Mechanism of Action of Primaquine Primaquine damage the mitochondria; the power house of parasite. With out energy the parasite cannot live Pharmacokinets of Primaquine Absorption It is well absorbed after oral administration. Distribution It is widely distributed in the body. Primaquine Pharmacology & Usage Details Medicine India. Mechanisms of drug action and resistance. Chloroquine + Primaquine Pharmacology & Usage Details Medicine India. In this video, I will explain into one of the main antimalarial drug, chloroquine. Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive. A recent publication has shown that primaquine, a drug used to clear liver-stage Plasmodium vivax infection, acts as a chloroquine-resistance reversing agent for Plasmodium falciparum in culture. Primaquine is active as a chloroquine-resistance reverser at concentrations that could be clinically relevant. Chloroquine mechanism of drug action and resistance in Plasmodium falciparum. Slater AF1. Author information 1Picower Institute for Medical Research, Manhasset, NY 11030. Quinoline-containing drugs such as chloroquine and quinine have had a long and successful history in antimalarial chemotherapy.