What is the mechanism of action of chloroquine and primaquine

Discussion in 'Canada Pharmaceuticals Online' started by fusiongr, 03-Mar-2020.

  1. ICQ-mag New Member

    What is the mechanism of action of chloroquine and primaquine

    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Chloroquine binds to heme or FP to form the FP-chloroquine complex; this complex is highly toxic to the cell and disrupts membrane function. Action of the toxic FP-chloroquine and FP results in cell lysis and ultimately parasite cell autodigestion. In essence, the parasite cell drowns in its own metabolic products. Malaria is a protozoan infection, caused by the bite of the female Anopheles mosquito. This article reviews the various antimalarial drugs, mechanisms of action, adverse effects/toxicity, and drugs of choice. Important therapeutic aspects of individual drugs will also be covered. The exact mechanism by which chloroquine inhibits hemozoin formation is not known, but chloroquine can bind heme and this binding may prevent the heme from being incorporated into the hemozin crystal. Parasite killing is therefore a result of the accumulation of metabolic wastes ie, heme associated with the digestion of hemoglobin.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    What is the mechanism of action of chloroquine and primaquine

    CHLOROQUINE PHOSPHATE, USP, Antimalarial Drugs — Quinine, Quinidine, Sulfonamides, Chloroquine and More

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  7. Primaquine About Primaquine 8-Aminoquinolone compound, Antimalarial. Mechanism of Action of Primaquine Primaquine damage the mitochondria; the power house of parasite. With out energy the parasite cannot live Pharmacokinets of Primaquine Absorption It is well absorbed after oral administration. Distribution It is widely distributed in the body.

    • Primaquine Pharmacology & Usage Details Medicine India.
    • Mechanisms of drug action and resistance.
    • Chloroquine + Primaquine Pharmacology & Usage Details Medicine India.

    In this video, I will explain into one of the main antimalarial drug, chloroquine. Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive. A recent publication has shown that primaquine, a drug used to clear liver-stage Plasmodium vivax infection, acts as a chloroquine-resistance reversing agent for Plasmodium falciparum in culture. Primaquine is active as a chloroquine-resistance reverser at concentrations that could be clinically relevant. Chloroquine mechanism of drug action and resistance in Plasmodium falciparum. Slater AF1. Author information 1Picower Institute for Medical Research, Manhasset, NY 11030. Quinoline-containing drugs such as chloroquine and quinine have had a long and successful history in antimalarial chemotherapy.

  8. plaksa): XenForo Moderator

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  9. Seoart XenForo Moderator

    Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Hydroxychloroquine - Wikipedia Hydroxychloroquine Plaquenil Hydroxychloroquine DermNet NZ
  10. KornevMG User

    My Take on New Ocular Screening Guidelines for Plaquenil RheumNow. Multifocal Electroretinopathy measures electrical responses of various cell types in the retina. It is thought that although the bull’s eye seen on ophthalmic exam represents a disruption of the pigmented part of the retina, it is the photoreceptors that are the targets of hydroxychloroquine toxicity.

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  11. gres01 Well-Known Member

    Plaquenil and hypoglycemia - Sjogren's World Re Plaquenil and hypoglycemia Reply #3 on March 05, 2011, PM I never did take plaquenil when it was offered by the rheumatologist, mainly because I had serious shingles which affected my eyes and I was afraid to take anything that might cause more problems with my eyes at the time.

    Plaquenil/hydroxychloroquine and hypoglycemia" Lupus.