Yesterday my rheumatologist started me on hydroxychloroquine as well. Is anyone else on this combination and have you had any problems with it as I know hydroxychloroquine can cause eye sight problems. Prednisone and hydroxychloroquine Generic made by plaquenil manufacturer Hydroxychloroquine and allergy testing Dec 15, 2010 hello hope everyone is well just a quick question, i have been on methotrexate for 2 months increasing from 7.5 to 15 and now to 25mg.weekly now been given plaquenil 400mg daily, has anyone else been on this mixture and has it worked or how long should i wait to see if it works. Results from a study published in the New England Journal of Medicine have demonstrated that a combination of conventional DMARDs, an approach called “triple therapy” which includes methotrexate, sulfasalazine, and hydroxychloroquine, can provide significant benefits in patients with RA who have. Hydroxychloroquine is often taken in combination with other drugs such as methotrexate. Are there any reasons I won't be prescribed hydroxychloroquine? Before starting on hydroxychloroquine your doctor may take a blood test to check that your liver and kidneys are working normally, but you won't need any regular blood tests during the treatment. Recently my eyes have felt sore and, after posting a question on this site, I am seeing my GP on Monday. Thanks Hi Catjones I have been taking this combination, started on both of them in January this year. Combination methotrexate and plaquenil Interactions between Glucosamine-Methylsulfonylmethane., Combinations of conventional & biologic DMARDs I don't like plaquenil Hydroxychloroquine may be used as part of a combination therapy. That means you may need to take it with other drugs. Taking methotrexate with hydroxychloroquine has not been studied. It may. Hydroxychloroquine Side Effects, Dosage, Uses, and More. Hydroxychloroquine Side-effects, uses, time to work. Effects of methotrexate and hydroxychloroquine combination.. Clinical practice guidelines recommend use of combination DMARDs such as hydroxychloroquine plus methotrexate for patients with a disease duration less than 6 months and moderate disease activity and poor prognostic features and is an option for high disease activity and poor prognostic features. OBJECTIVE To examine the bioavailability of methotrexate MTX in the presence of hydroxychloroquine HCQ, and vice versa, to determine a possible pharmacokinetic explanation for the observation that combination treatment of rheumatoid arthritis with MTX and HCQ has been shown, clinically, to be more potent than MTX used alone. I am on both methotrexate and plaquenil. I have been on plaquenil for over a year and a half and methotrexate since September. I have had no side effects from either one. I get my eyes checked every six months and I am now at once a month on blood work for my liver enzymes used to be every 2 weeks.