While the mechanism is poorly understood, pregnant women have a reduced immune response and therefore less effectively clear malaria infections. In addition, malaria parasites sequester and replicate in the placenta. Hydroxyl chloroquine Moa of chloroquine in malaria Pregnancy and Chloroquine According to the Centers for Disease Control and Prevention CDC, chloroquine is considered safe to use during pregnancy. Tell your doctor if you're pregnant or might. Symptomatic and asymptomatic malaria infections during the first trimester of pregnancy were associated with miscarriage; treatment appeared to be safe. Malaria during pregnancy has adverse effects, including maternal mortality, miscarriage, and low birthweight. Chloroquine or hydroxychloroquine are considered safe to use in all trimesters of pregnancy. Mefloquine is the agent of choice for chloroquine-resistant areas, and evidence suggests it is not associated with an increased risk to the fetus. Malaria infection during pregnancy can lead to miscarriage, premature delivery, low birth weight, congenital infection, and/or perinatal death. Pregnant women are three times more likely to develop severe disease than non-pregnant women acquiring infections from the same area. Is chloroquine safe during pregnancy Chloroquine Oral Uses, Side Effects, Interactions., First-Trimester Malaria Treatment and Outcomes What is plaquenil use forHydroxychloroquine to treat hair lossHydroxychloroquine sulphate dosageCitalopram and hydroxychloroquine You can take some anti-malaria medicines safely during pregnancy, but should avoid others. For example Chloroquine and proguanil usually combined can be used in pregnancy, but may not offer enough protection against malaria in many regions, including Africa. You'll also need to take a 5mg supplement of folic acid if you're taking proguanil. Can I take anti-malaria medication if I'm pregnant? - NHS. Prophylactic use of antimalarials during pregnancy. Aralen chloroquine Malaria Drug Side Effects & Dosage. Is it safe to take chloroquine in pregnancy? There is no evidence that chloroquine is harmful to an unborn baby, although more information about its use in pregnancy ideally needs to be collected. If you are travelling to certain regions you may be advised to take chloroquine. You should not avoid taking chloroquine because you are pregnant. Summary. Alternative drugs to chloroquine are required to prevent the deleterious effects of malaria in pregnancy. Fear of potential toxicity has limited antimalarial drug use in pregnancy. Animal toxicity studies have documented teratogenicity when antimalarials are administered at high dosages. Because no information is available on the daily use of chloroquine during breastfeeding, hydroxychloroquine or another agent may be preferred in this situation, especially while nursing a newborn or preterm infant. Drug levels. Chloroquine has a serum half-life of over a month.