B, Brown pigmentation on the legs in another patient who had systemic lupus erythematosus associated with diffuse discoid lupus. The skin biopsy was performed on the brown area distant from discoid lesions. Chloroquine phosphate leth Hydroxychloroquine and metformin Aug 14, 2013 Hydroxychloroquine is an antimalarial medication that can cause hyperpigmentation of nails, mucosa, and skin 1–5. Retrospective studies cite the incidence of drug-related hyperpigmentation from hydroxychloroquine to be as high as 33% of individuals. Elder abuse is a cause of significant morbidity and mortality in older individuals 7–9. Hydroxychloroquine induced cutaneous pigmentation. cular hemosiderin on special staining. 3 Cutaneous hyperpigmentation has been suggested as a marker. 4 Millard TP, Kirk A, Ratnavel R. Cutaneous hyperpigmentation during therapy with hydroxychloroquine. Clin Exp Dermatol 2004;–3. 5 Dwyer CM, Cuddihy AM, Kerr RE, et al. Skin. Some side effects of hydroxychloroquine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. B, Presence of iron in the same areas of the dermis (Perls staining, original magnification ×100). Pub Med Google Scholar Crossref Morrison LK, Nordlund JJ, Heffernan MP. Pub Med Google Scholar Costedoat-Chalumeau N, Galicier L, Aumaître O, et al; Group PLUS. Google Scholar Costedoat-Chalumeau N, Amoura Z, Hulot JS, et al. Pub Med Google Scholar Crossref Costedoat-Chalumeau N, Leroux G, Piette J-C, Amoura Z. A, Interstitial and perivascular brown pigmented granules in the dermis (hematoxylin-eosin-safran staining, original magnification ×100). Cutaneous hyperpigmentation during therapy with hydroxychloroquine Cutaneous Hyperpigmentation During Therapy With., Hydroxychloroquine induced cutaneous pigmentation a. Hydroxychloroquine treatment of rheumatoid arthritisPlaquenil and valacyclovir Persistent cutaneous hyperpigmentation due to hydroxychloroquinone one year after therapy discontinuation L Katie Morrison MD 1,2, James J Nordlund MD 1, Michael P Heffernan MD 1 Dermatology Online Journal 15 12 15 1. Center for Clinical Studies, Houston, Texas 2. Wright State Dermatology, Dayton, Ohio Abstract Persistent cutaneous hyperpigmentation due to.. Hydroxychloroquine Side Effects Common, Severe, Long Term.. PDF Cutaneous Hyperpigmentation During Therapy with.. Hydroxychloroquine does cross the placenta and is considered Category D in pregnancy see DermNet NZ's pages on Safety of medicines taken during pregnancy and on Lactation and the skin. However, in multiple studies, hydroxychloroquine use has not been associated with congenital disabilities, stillbirth, prematurity, low birth weight, fetal. Cutaneous hyperpigmentation during therapy with hydroxychloroquine. Amichai B1, Gat A, Grunwald MH. Author information 1Huzot Clinic, Clalit Health Services, Ashkelon, Israel. [email protected] What is drug-induced skin pigmentation. Drug-induced skin pigmentation accounts for 10–20% of all cases of acquired hyperpigmentation. Pigmentation may be induced by a wide variety of drugs; the main ones implicated include non-steroidal anti-inflammatory drugs NSAIDs, phenytoin, antimalarials, amiodarone, antipsychotic drugs, cytotoxic drugs, tetracyclines, and heavy metals.