Most importantly, you help support continued development of this site. The majority of cases of retinotoxicity have occurred in patients that have had a cumulative dose exceeding 1000g of hydroxychloriquine (Plaquenil). This level is reached in about 7 years with the most common daily dose of Plaquenil, 400 mg/day (200 bid). Hydroxychloroquine sulfate 200 mg tablet Plaquenil insomnia Rashes due to hydroxychloroquine Known risk factors for cervical cancer include Lifestyle. Sexual history Certain types of sexual behavior are considered risk factors for cervical cancer and HPV infection, including early onset of sexual activity beginning in the early teen years, sex with multiple partners, and sex with someone who has had multiple partners. Smoking A woman who smokes doubles her risk of cervical cancer, because carcinogens that are inhaled are partly excreted in cervical mucus and bathe the cervix. Continued DMARDs and Cancer Risk. Methotrexate is often the first treatment given to people with RA. But it could make you more likely to get some cancers, especially skin cancer. Lupus and cervical cancer. Certain studies have shown an elevated risk of cervical cancer and abnormal PAP tests in women with lupus. One study linked the increased incidence of abnormal PAP tests with histories of sexually transmitted disease, contraceptive use, and immunosuppressive medications. It now solely uses real body weight (rather than ideal body weight) based on new recommendations from a 2014 study (1). Disclaimer: This tool is designed to help eye care professionals better understand the risk the of retinotoxicity from hydroxychloroquine. Please note: This calculator was modified in 9/2015. Plaquenil cervical cancer risk Cervical Cancer Risk Factors Risk Factors for Cervical Cancer, RA Drugs and Cancer What’s the Link? Hydroxychloroquine class action lawsuit Persistent human papillomavirus HPV infection is already a known major risk factor for cervical cancer, one that is affected by a number of variables, including older age, the HPV genotype, any coexisting infections, inflammation, and immunosuppression. Women With Lupus at Risk for Cervical Cancer. Are Individuals With Lupus At A Greater Risk For Cancer.. Cervical Cancer Risk Factors -. Aug 07, 2019 For most women, HPV will go away on its own; however, if it does not, there is a chance that over time it may cause cervical cancer. Other things can increase your risk of cervical cancer— Having HIV the virus that causes AIDS or another condition that makes it hard for your body to fight off health problems. The most important risk factor for cervical cancer is infection with HPV. HPV is common. Most people are infected with HPV when they become sexually active, and most people clear the virus without problems. There are over 100 different types of HPV. A number of studies suggest that patients with systemic inflammatory diseases and systemic lupus erythematosus SLE in particular, may be at increased risk for persistent HPV infection, high-grade cervical dysplasia, and cervical cancer. 5 This heightened vulnerability may be due to an immunocompromised state from the disease itself, the immunosuppressive drugs ISDs used, or a combination of both resulting in a diminished ability to clear the HPV infection. 6 Few studies to date have.