I started Plaquenil last week and so far the side effects are dizziness, nausea and tummy feeling weird. I was just wondering has long it takes to adjust and if taking twice the dose will result in higher discomfort. How does plaquenil treat rheumatoid arthritis Plaquenil and blood pressure I take plaquenil too, it takes a few months to reach therapeutic levels. The eye exam is due to possible retinal damage. I just recently saw a retinal specialist and he said that it was pretty rare to get any damage but they THEY! have to recommend the tests anyway. Several risk factors may increase the likelihood of retinal toxicity from Plaquenil such as, age of greater than 60 years, daily dose more than 6.5 mg/kg; use of the drug more than 5 years, obesity, preexisting retinal disease and, renal or liver failure. Shadeseeker 07/01/2009. I take Plaquenil for Lupus and it takes 4 to 6 months. For me, it always seems to take 6 months for me to feel the full effect and a marked improvement in my fatigue & joint pain. Also, any tips on how to keep up with taking them on schedule? I have to take Plaquenil, Naturethroid and Vitamin D, everyday . I'm having lots of trouble falling asleep (been having it for a while), not sure if it's getting worse due to the pills. How longbto take plaquenil after alcohol Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis, The Risk of Retinal Toxicity with Plaquenil Chloroquine resistant falciparum malaria treatmentLichen planus and plaquenilThe drug plaquenil Alcohol and plaquenil? By curious101. New Reply Follow New Topic. curious101 over a year ago. Can you drink alcohol while taking Plaquenil? I don't drink everyday, but have had some drinks while on NSAIDS and Prednisone and have not had any bad effects. What happens with Plaquenil? Alcohol and plaquenil? Anti-Inflammatories discussions.. When does the plaquenil kick in? DailyStrength. Immune & Autoimmune - Lupus Plaquenil - Can It Work Quickly?. It sounds like you're doing a good job of it yourself, but I would say go very slowly off of it. Plaquenil takes a long time to build up in your body and therefore also will take awhile to really leave your body as well. So you're not going to get a good picture in one months time what the reduction of the plaquenil has had on you. Symptoms can start to improve in one to two months, but it may take up to six months before the full benefits of this medication are experienced. Side Effects Hydroxychloroquine typically is very well tolerated. I currently take plaquenil, azathioprine, and 2 BP nerd 1 prescribed for migraines years before lupus dx. Lately, I’ve been experiencing extreme itchiness, almost painful sometimes. It lasts for almost an hour after I’m out of the shower. I’m thinking it’s related to the azathioprine because it didn’t start until after I started it.