It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes, which transmit the parasites that cause the infection, usually in tropical and subtropical parts of the world. Plaquenil use and weight and maculopathy Plaquenil metabolism 2d6 Plaquenil toxicity 10-2 SIDE EFFECTS. The following adverse reactions have been identified during post-approval use of PLAQUENIL or other 4-aminoqunoline compounds. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. WebMD explains the causes, symptoms, and treatment of Sjogren's syndrome, a condition in which your eyes, mouth, and other parts of your body get dried out. Skip to main content. Steps can be taken to reduce this risk. These include using the lowest dose that controls the joint pain, taking the NSAID with food, choosing an NSAID with a lower risk of gastrointestinal side effects, and taking a proton-pump inhibitor, such as omeprazole or pantoprazole, along with the NSAID on a daily basis. For example, it may be combined with an antibiotic to treat chronic Q-fever, which humans usually catch from farm animals or raw milk. Plaquenil is used to treat other types of infections too. Does plaquenil reduce rf in sjogrens Inflammatory Osteoarthritis And Plaquenil, Sjogren's Syndrome Symptoms, Causes, Diagnosis, Treatment Plaquenil dosage 400 mg Study Raises Questions about Sjogren's and Plaquenil Image Source For many patients with Sjogren's, Plaquenil hydroxychloroquine has long been the go to drug that their doctors prescribe. Most docs now prescribe it at 400 mg/day to start, then once you get the effect, you lower your daily dose to reflect your size. For most petite women. Study Raises Questions about Sjogren's and Plaquenil. Joint Pain - Johns Hopkins Sjogrens Center. Plaquenil and its affect on the immune system DailyStrength. My ALT and AST have gone from low teens to mid 50s in 6 months. I know that is not really so high but she is concerned. She cut my pravastatin dose in half and said I need to talk to my rheum about the Plaquenil 400 mg a day. Does plaquenil affect liver enzymes? I hate to decrease - I feel it has helped me quite a bit. Yesterday I was cruising around on the Sjogren's World Forum and came across an interesting topic of discussion. One of the sjoggies there who is diabetic noted that her blood sugars were consistently lower after she began taking Plaquenil hydroxychloroquine. Hydroxychloriquine is a disease modifying anti rheumatic drug DMARD commonly used as a first-line medication in the treatment of. Several risk factors may increase the likelihood of retinal toxicity from Plaquenil such as, age of greater than 60 years, daily dose more than 6.5 mg/kg; use of the drug more than 5 years, obesity, preexisting retinal disease and, renal or liver failure.