One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Lose weight after plaquenil Chloroquine in breastfeeding Sun sensitivity plaquenil Retrospective clinical data review by the Boston Image Reading Center. Main Outcome Measures SD-OCT findings suggestive of HCQ retinopathy before parafoveal ellipsoid disruption. Change in SD-OCT morphological appearance and retinal thickness of each of the nine subfields corresponding to the Early Treatment of Diabetic Retinopathy Study areas. Humphrey visual field 10-2 with C paracentral ring scotoma that correlates with retinal disease in the right eye, and D left eye. Spectral-domain optical coherence tomography of the E right and F left eye, whose arrow shows disruption of the ellipsoid zone in the outer retina within the parafoveal area with outer nuclear layer thinning. SD-OCT will reveal parafoveal thinning of the photoreceptor integrity line and the outer nuclear layer of the retina; this results in a "flattening" of the foveal depression and the "flying saucer sign" where the outer nuclear layer in the fovea's center is unaffected, and just around it this layer is much thinner the edge of the saucer. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Oct en face retina mesaurements plaquenil Plaquenil Uses, Dosage & Side Effects -, Automated Segmentation Measurements of the Outer Nuclear. New guidelines for plaquenil macuopathy Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Plaquenil Side Effects Common, Severe, Long Term -. Chloroquine And Hydroxychloroquine Toxicity - StatPearls.. Retinal Physician - Hydroxychloroquine Maculopathy An.. In early toxicity there are no visible signs, but field, OCT and mfERG changes can be detected. If abnormalities are present only unilaterally, investigate other causes besides hydroxychloroquine toxicity see “Differential Diagnosis of Bull’s-Eye Maculopathy”. This case demonstrates that the findings of HCQ retinopathy on en face structural OCT are analogous to those identified by current imaging modalities used for the screening and diagnosis of HCQ toxicity. En face structural OCT may be useful in the detection of HCQ-induced retinal toxicity. Optical Coherence Tomography, or OCT, is advanced technology used for retinal imaging and analysis. This technology provides highly detailed images of the retina as well as the optic nerve. These cross-sectional images are viewable in 2D and 3D, allowing for topographical mapping of the eye including macular thickness.