Chloroquine mechanism of resistance

Discussion in 'Canadian Pharmacies Online' started by xx5org, 04-Mar-2020.

  1. Ell New Member

    Chloroquine mechanism of resistance


    However, the reason for the lower accumulation of chloroquine was unknown. The resistant parasite has now been found to release chloroquine 40 to 50 times more rapidly than the susceptible parasite, although their initial rates of chloroquine accumulation are the same.

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    Apr 02, 2019 Mechanism of Action. Chloroquine is an antimalarial agent. While the drug can inhibit certain enzymes, its effect is believed to result, at least in part, from its interaction with DNA. However, the mechanism of plasmodicidal action of chloroquine is not completely certain. Activity in vitro and in vivo Chloroquine-resistant P. falciparum first developed independently in three to four areas in Southeast Asia, Oceania, and South America in the late 1950s and early 1960s. Since then, chloroquine resistance has spread to nearly all areas of the world where falciparum malaria is transmitted. ChloroquineResistance In Plasmodium Falciparum. With cholorquine there is emergence of resistance, which has limited its use. Primarily highly effective against febrile illness, relief is quickly achieved within 24 hours. It is easily available, well tolerated and cost effective but now uses are declining because of resistance. 1.

    These results suggest that a higher rate of chloroquine release explains the lower chloroquine accumulation, and thus the resistance observed in resistant Plasmodium falciparum. Verapamil and two other calcium channel blockers, as well as vinblastine and daunomycin, each slowed the release and increased the accumulation of chloroquine by resistant (but not susceptible) Plasmodium falciparum.

    Chloroquine mechanism of resistance

    Antimalarial drugs Mode of action and status of resistance, Drug Resistance in the Malaria-Endemic World - CDC

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  7. The clinical usefulness of chloroquine, and in some recent cases of quinine as well, has been much reduced by the evolution and spread of chloroquine resistant malaria parasites. The mechanism of resistance involves a reduced accumulation of the drug, although again the mechanism involved is controversial.

    • Chloroquine mechanism of drug action and resistance in..
    • Chloroquine – howMed.
    • Chloroquine C18H26ClN3 - PubChem.

    The molecular mechanism of resistance development to chloroquine is still not well understood. It is critical that its mechanism of action be well understood as it is a safe drug, well tolerated in the body and it is further moderately affordable 6. Resistance to chloroquine has, however, steadily spread since the 1960s from two foci, one in South America and one in South East Asia. Throughout the 1980s, chloroquine resistance spread through Africa, the global heartland of malaria mortality and morbidity, and there are very few effective and affordable drugs to take its place. Causes of resistance 12 3.1 Definition of antimalarial drug resistance 12 3.2 Malaria treatment failure 12 3.3 Mechanisms of antimalarial resistance 12 3.3.1 Chloroquine resistance 12 3.3.2 Antifolate combination drugs 13 3.3.3 Atovaquone 13 3.4 Factors contributing to the spread of resistance 13 3.4.1 Biological influences on resistance 13

     
  8. uryP User

    Selected from data included with permission and copyrighted by First Databank, Inc. Aspirin oral and bismuth subsalicylate oral Drug Interactions - RxList Pepto-Bismol Disease Interactions - Kaopectate, Pepto Bismol bismuth subsalicylate dosing, indications.
     
  9. user1138 New Member

    Liver Itch Detox Healthfully Liver itch is a common symptom of many patients who have conditions that affect the liver. This itch can develop at any time during the duration of the condition, and the symptom is usually chronic. Treatment for the itch is unknown. However, liver detoxification is said to stop the itching 3.

    Chloroquine-induced Pruritus
     
  10. Hind New Member

    Plaquenil Sanofi-aventis U. S. LLC FDA Package Insert. Dosage and Administration. One tablet of hydroxychloroquine sulfate, 200 mg, is equivalent to 155 mg base. Lupus Erythematosus. Initially, the average adult dose is 400 mg =310 mg base once or twice daily. This may be continued for several weeks or months, depending on the response of the patient.

    HYDROXYCHLOROQUINE - Hydroxychloroquine sulfate