Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Antimalarials hydroxychloroquine Chloroquine aralen cost Hydroxychloroquine Plaquenil and chloroquine cause ocular toxicity to various parts of the eye such as the cornea, ciliary body, and retina. Chloroquine can also induce cataract formation; however, no reports of hydroxychloroquine and cataract have been reported. This article focuses upon hydroxychloroquine retinopathy. Disease A chemical peel can cause treated skin to become darker than normal hyperpigmentation or lighter than normal hypopigmentation. Hyperpigmentation is more common after superficial peels, while hypopigmentation is more common after a deep peel. Changes in skin color are more common in people who have darker skin and can be permanent. Infection. Skin Hyperpigmentation with Hydroxychloroquine. Hydroxychloroquine Plaquenil is a common trade name is an anti-inflammatory oral medication that is commonly used to treat many autoimmune diseases. In the hair clinic, we use it for diseases such as lichen planopilaris, frontal fibrosing alopecia, pseudopelade and discoid lupus. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil hyperpigmentation Systemic Scleroderma Skin Involvement Hyperpigmentation and., Chemical peel - Mayo Clinic Discoid lupus and plaquenil Find information about common, infrequent and rare side effects of Plaquenil Oral. Common and Rare Side Effects for Plaquenil Oral. Skin Pigmentation with Hydroxychloroquine Plaquenil — Donovan Hair Clinic. Will you have Skin discoloration - bluish with Plaquenil.. The incidence of hydroxychloroquine-related hyperpigmentation in patients with systemic lupus erythematosus is about 7%, but unlike hydroxychloroquine-related retinopathy, there is no clear association with cumulative dose or duration of use.1 Roughly half of cases occur in the first five years of treatment. Druginformer Identified Side Effects Arthralgia, Chest pain, Pruritus, Skin hyperpigmentation, Oral disorder, Lupus-like syndrome. Posted By Anonymous in on July 11, 2006 @ am “. Plaquenil worked well on my symptoms, but it started to make me itchy and caused skin pigmentation. Plaquenil or hydroxychloroquine has been known to cause a darkened discoloration of skin and/or mucous membranes. This is considered an adverse reaction and should be discussed with your prescriber. It is important to evaluate this color change to make sure there is nothing else wrong.