In many cases, once the offending drug has been stopped, fading of the lesions occurs. However, the pigmentation may last a long time or become permanent. Method of action of chloroquine Plaquenil back pain and headache Gray nails and plaquenil On examination, a telltale sign of hydroxychloroquine toxicity is a bilateral change in the retinal pigment epithelium of the macula that gives the commonly described appearance of a bull’s-eye. This is a late finding, however, and too late for screening to be useful. Conclusions HCQ-induced pigmentation is considered uncommon adverse effect of HCQ, with a prevalence rate of 49.2% indicated in this study. Furthermore, history of bruising, sun exposure, and the presence of mucous membrane pigmentation are possible predisposing factors. HCQ is often prescribed for longer durations and may be associated with cutaneous adverse effects such as yellow-brown or slate-grey pigmentation, bleaching of hair, exacerbation of pre-existing psoriasis, cutaneous rashes and pruritus. 1 Cutaneous pigmentation occurs in 10%–30% patients, most commonly over shins. Download PDF Many systemic medications may cause retinal toxicity. Because many drugs that induce skin pigmentation also cause photosensitivity reactions, sun protection is usually recommended. Hydroxychloroquine-induced pigmentation Woman in grey hydroxychloroquine-induced hyperpigmentation BMJ Case., Prevalence and risk factors of hyperpigmentation induced by. Chloroquine dna intercalationPlaquenil blue skinHydroxychloroquine dosage for malaria prophylaxisChloroquine effective against malaria In 12 of 41 29% of the hydroxychloroquine users, we conclude a hydroxychloroquine-induced pigmentation. There were 11 women and one man with a mean age of 43 years and all of them were systemic. Hydroxychloroquine-Induced Hyperpigmentation. Hydroxychloroquine induced cutaneous pigmentation a.. Hydroxychloroquine-Induced Retinal Toxicity - American Academy of.. The few reports of bluish pigmentation with HCQ described resolution within a few months or did not specifiy the duration of pigmentation after discontinuation of the drug 4, 5, 6. Hydroxychloroquine is converted to an inactive metabolite in the liver and excreted in urine 25% in the active form and bile. Hydroxychloroquine pigmentation can occur within 1 year after starting therapy 4, 12, 13, 17. The skin discoloration has no systemic adverse sequelae. The skin discoloration has no systemic. Introduction Hydroxychloroquine is an antimalarial agent widely prescribed in internal medicine, rheumatology and dermatology. Its use can be complicated by various side effects including skin pigmentation. Objectives The aim of the study is to review epidemiological, clinical features and risk factors of hydroxychloroquine-induced pigmentation.