Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Chloroquine glycosylation Plaquenil substitute Patients taking drugs from certain classes should be educated about an alarming side effect. A recent literature review published in the British Journal of Clinical Pharmacology identified 12 total drug classes that can cause Raynaud’s disease, a syndrome in which blood vessels constrict more than normal in response to cold temperatures or stress. Both my father and I have Raynaud's, but with him it. is a primary raynauds, and with me it is secondary to. my RA. I have not heard of Plaquenil for raynaud's, but I did take it for RA with good result. My dad was. diagnosed Procardia for his Raynaud's and got much. better. Prior to that his nose was always bright May 25, 2010 Hi! I think Plaquenil is the cause of my extreme fatigue too. I am not anemic at this time and I get exhausted just trying to get through the day. I have also been on Plaquenil about three months. All of my arthritis swelling and pain are gone, but the fatigue will not let up! Hope things change for you. Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. This medicine is not effective against all strains of malaria. Raynauds plaquenil New Shingles Vaccine Great News for RA Community., Re Plaquenil and Secondary Raynaud's - Health, Medicine. Chloroquine tablets to buy asda First off, let’s define what a connective tissue disease, or disorder, is. Connective tissue diseases CTDs actually refer to a large group of diseases that primarily target the body’s connective tissue the “glue” that supports organs and other parts of the body. Mixed Connective Tissue Disease MCTD Explained.. Is extreme fatigue a side effect of Plaquenil?. Raynaud's disease - Symptoms and causes - Mayo Clinic. Plaquenil isn a antiparasitic drug with anti-inflammatory affect. I have done a lot of research on this drug and haven't run into anybody who has complained of the withdrawal effect. Over the years on this site we have had quite a few people post that they didn't think that the plaquenil was working so they would stop taking it. But, I would say that you might have been suffering from Raynaud's Syndrome and Plaquenil is one of the drugs used to treat that syndrome. Raynaud's syndrome is a disorder that affects the blood vessels in the fingers, toes, ears, and nose. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria.