Byproduct of chloroquine synthesis

Discussion in 'Chloroquine Drug' started by Gilgamesh, 29-Feb-2020.

  1. BSOD Moderator

    Byproduct of chloroquine synthesis


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Figure 1. Structure of the chloroquine synthesis “active impurity” “byproduct” 1 which led Sterling Drug to the identification of nalidixic acid 2; quinolone 1 was also listed as a patent example in ICI’s GB830832. Shown are the core structures and numbering of quinolones and corresponding 1,8-naphthyridones. Since the nalidixic acid, the first marketed antimicrobial agent of quinolone family, was introduced into the clinic about 50 years ago as a byproduct of chloroquine synthesis, four generations of quinolones have been developed successfully. Abstract. The drug chloroquine is bactericidal for Bacillus megaterium; it inhibits DNA and RNA biosynthesis and produces rapid degradation of ribosomes and dissimilation of ribosomal RNA. Inhibition of protein synthesis is also observed, evidently as a secondary effect. Inhibition of DNA replication is proposed as a general mechanism of the antimicrobial action of chloroquine.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Byproduct of chloroquine synthesis

    Chloroquine Oral Uses, Side Effects, Interactions., Multi-targeting exploration of new 2-aminothiazolyl.

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  7. Chloroquine is a 9-aminoquinoline known since 1934. Apart from its well-known antimalarial effects, the drug has interesting biochemical properties that might be applied against some viral infections. Chloroquine exerts direct antiviral effects, inhibiting pH-dependent steps of the replication of several viruses including members of the flaviviruses, retroviruses, and coronaviruses. Its best.

    • Effects of chloroquine on viral infections an old drug..
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    Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication. A New Synthesis of Chloroquine The efficacy of chloroquine, once the drug of choice in the fight against Plasmodium falciparum, is now severely limited due to widespread resistance. Amodiaquine is one of the most potent antimalarial 4-aminoquinolines known and remains effective against chloroquine-resistant parasites, but toxicity issues linked to a quinone-imine metabolite limit its clinical use. In search of new compounds.

     
  8. DYADYA65 User

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  10. eugeny_kr User

    Taking Plaquenil for Rheumatoid Arthritis A rare side effect of Plaquenil involves visual changes or possible loss of vision—the side effect that is most worrisome for patients. The aforementioned rare side effect that affects vision hydroxychloroquine retinopathy, if caught early, may improve after discontinuation of Plaquenil.

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