It does not work against certain types of malaria (chloroquine-resistant). The United States Center for Disease Control provides updated guidelines and travel recommendations for the prevention and treatment of malaria in different parts of the world. Side effects bruising methotrexate plaquenil Lyrica and plaquenil Drug information provided by IBM Micromedex Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. I had severe nausea and diarrhea when started on Plaquenil 2 X 200mg tabs once daily almost 3yrs ago. As I also have Crohn's Disease and an Ileostomy this was putting me at serious risk. I was told to stop the Plaquenil until my GI symptoms disappeared. Side Effects Nausea, stomach cramps, loss of appetite, diarrhea, dizziness, or headache may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Remember. This medication is also used, usually with other medications, to treat certain auto-immune diseases (lupus, rheumatoid arthritis) when other medications have not worked or cannot be used. Discuss the most recent information with your doctor before traveling to areas where malaria occurs. Can generic plaquenil cause diarrhea Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects., Plaquenil aka HCQS – Anyone on this getting severe. Hydroxychloroquine and the flu Diarrhea is found among people who take Plaquenil, especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months, also take medication Enbrel, and have Pain. This study is created by eHealthMe based on reports of 57,706 people who have side effects when taking Plaquenil from Food and Drug Administration FDA, and. Will you have Diarrhea with Plaquenil - eHealthMe. Plaquenil Oral Uses, Side Effects, Interactions.. Plaquenil Hydroxychloroquine Side effects, Images, Uses.. I have been on Plaquenil and can tell you my diarrhea started within days of starting the med. My doctor warned me that diarrhea and weight loss were side effects. I said, "Well, I am usually very constipated and could stand to lose 10 pounds so this could be a good thing." haha. I am NOT constipated any more but have not lost any weight either. I suspect plaquenil for giving me some episodic diarrhea. I am 100 mg dose and take it with my supper. Did they happen to anyone else and did it eventually stop with the diarrhea side effect? It helps so much with the fatigue and pain. I have a sensitive stomach and perhaps I shouldn't have eaten that salad for lunch yesterday. Question. I started taking Plaquenil 4 weeks ago for non specific autoimmune disease as indicated by ANA. Symptoms were low grade temperature off and on for a year, joint pain and fatigue. I have already felt some relief. Some nauseau at first but less problem with fever and joint pain. But, now I have started having stomach cramps and diarrhea.