People who have this virus and take certain disease-modifying medications for MS may be at risk for a rare, yet serious, disease. The disease is called progressive multifocal leukoencephalopathy (PML). How to pay for plaquenil Plaquenil and puffy face The biology of MS. Peripheral nervous system. While the central nervous system CNS is composed of the nerves of the brain and the spinal cord, the peripheral nervous system PNS describes all the nerves that serve the sensory organs, muscles, glands, and other parts of the body outside the brain and spinal cord. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. All age groups are susceptible to the virus, but elderly patients with comorbidities are more likely to experience severe illness. The mean age of hospitalized patients in an early reports was 59 years old, with a predominance of male patients 56%. The mean incubation time has been reported as 4.1 to 7 days. In MS, it is the loss of myelin that damages nerve function. It results when JC virus infects oligodendrocytes, cells that insulate nerve cells with myelin. Jc virus and plaquenil Pembrolizumab Treatment for Progressive Multifocal., Hydroxychloroquine Plaquenil Hydroxychloroquine sjogren's syndromeSeronegativera plaquenilHydroxychloroquine drug classification Progressive multifocal leukoencephalopathy PML is an opportunistic infection of the central nervous system CNS, caused by the polyoma virus JC virus JCV and characterized by focal demyelination. 1,2 The virus has worldwide distribution, with a seroprevalence of 39% to 69% among adults. 3-6 Primary JCV infection usually occurs. PML/JCV Adult and Adolescent Opportunistic Infection.. Coronavirus Disease 2019 COVID-19 Health Professionals. Rituxan Disease Interactions -. Hydroxychloroquine Plaquenil is a drug that is classified as an anti-malarial drug. Plaquenil is prescribed for the treatment or prevention of malaria. It is also prescribed for the treatment of rheumatoid arthritis, lupus, and the side effects of lupus such as hair loss, joint pain, and more. The case involves a 62-year-old white female with SLE who died of progressive multifocal leukoencephalopathy caused by JC virus within the central nervous system. She was on hydroxychloroquine Plaquenil for SLE for 8 years. The John Cunningham virus, known more commonly as the JC virus, is a very common virus in the United States. According to the World Journal of Neurosciences, between 70 and 90 percent of people in the world have the virus.