I don't get many side effects generally, but with prednisone I DO. It does help, but this can't be a long term affair. Plaquenil is a great drug (I have no experience with it, but many people with lupus take it). I'd ask your rheumy about it and have them explain why they made that choice for you. Prednisone is an intermediate acting corticosteroid-which means it has direct anti-inflamitory properties that take effect begining in a few hours. Is plaquenil another option instead of the prednisone? It is ment to get this undercontrol now and diminish your pain. What will happen if i don't take plaquenil What does plaquenil do for porphyria Hydroxychloroquine side effects diarrhea Lysosomotropic agent chloroquine My friend was on long-term prednisone after an organ transplant not-lupus related and she was blown-up and swollen like a balloon. It scared me at first to think of vision problems with Plaquenil, but I found a good eye doctor who checks my eyes every 6 months and tells me what to watch out for. Drugs & Medications Plaquenil. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. Like the others have said it's best not to take meds prescribed for reflux, such as Omeprazole or Lanzoprazole, at the same time as Plaquenil as they can make it less effective. I need to leave at least a couple of hours between my morning Lanzoprazole and my first dose of Plaquenil otherwise I feel sick. It has not direct anti-inflamitory properties and instead works on the immune system-though the mechanism is not known. Plaq is a longer time medication it may take two months before their is a noticable difference. What time should i take my prednisone and my plaquenil First time on Plaquenil -, Plaquenil Oral Interactions with Other Medication Hydroxychloroquine photosensitivityChloroquine in cancer therapy a double edged sword of autophagyDeschloroquine used on chloroquine resistant parasites The usual starting dose of Plaquenil is 200 mg twice a day or 400 mg once a day, administered orally, in people weighing 80 kg or more. The usual dosage works for most people who take Plaquenil, but it is possible to increase or decrease the dose based on individual needs. Taking Plaquenil for Rheumatoid Arthritis. When best time of day to take plaquenil? - LUPUS UK. Prednisone and Plaquenil DailyStrength. I have been on plaquenil for 5 years and immune suppressants for three and this is the first time they have said anything about stopping when taking antibiotics. I would have asked, but the appointment was running super late and my blood pressure was way up by the time the dr came into see me. Plaquenil and Prednisone. By Ang May 4, 2015 at pm. I have been on plaquenil for about 3 months and prednisone for about 5 months. Daily I still get pain and stiffness in my hands and feet. Use this medication regularly in order to get the most benefit from it. If you are taking it on a daily schedule, take it at the same time each day. Take this medication exactly as prescribed.