One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Apo-hydroxychloroquine for swelling Interactions with plaquenil and leflunomide Hydroxy chloroquine rheumatoid arthritis side effects Plaquenil is less toxic than chloroquine; however, long-term use of either drug can result in macular toxicity, leading to devastating irreversible vision loss. Plaquenil Side Effects by Likelihood and Severity INFREQUENT side effects. If experienced, these tend to have a Severe expression. A Disorder Of The Retina Of The Eye; Hydroxychloroquine has significantly less retinal toxicity and has largely replaced chloroquine as a treatment of inflammatory disease. Unfortunately, the retinal damage from these medications is largely irreversible, so it is critical to detect early retinal toxicity in the hopes of limiting the extent of visual loss. Sign/Symptoms It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Macular thinning plaquenil Epiretinal Membrane Symptoms, Causes, Treatments, Common and Rare Side Effects for Plaquenil Oral High cost of hydroxychloroquineCan i use of hydroxychloroquine with sulfur allergyWhat is the dosage of plaquenil The American Academy of Ophthalmology released an updated set of screening recommendations for hydroxychloroquine Plaquenil and chloroquine to account for the many studies that have shown the effects of these medications on the retina 1. It succinctly makes the case for screening, and Hydroxychloroquine And Chloroquine Screening 2016 AAO.. Hydroxychloroquine Plaquenil Toxicity and.. Retinitis Pigmentosa Macula and Retina Institute. Selective Thinning of the Perifoveal Inner Retina as an Early Sign of Hydroxychloroquine Retinal Toxicity Sirichai Pasadhika, 1 Gerald A Fishman, 1 Dongseok Choi, 2 and Mahnaz Shahidi 1 1 Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Hydroxychloroquine Plaquenil is a disease-modifying antirheumatic drug that is commonly used to reduce arthritic pain and swelling. Signs and symptoms. “The association of Plaquenil therapy with macular toxicity is well established,” said Michael F. Marmor, MD, at the Byers Eye Institute at Stanford University.