Chloroquine lysosomal accumualtion

Discussion in 'Health Canada Drug Database' started by Arhira, 23-Feb-2020.

  1. poioii XenForo Moderator

    Chloroquine lysosomal accumualtion


    Chloroquine is the most widely used drug against malaria, except for those cases caused by chloroquine resistant Plasmodium falciparum. To prevent malaria: Start taking the medicine 2 weeks before entering an area where malaria is common.

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    Sep 15, 2013 Accumulation of chloroquine in the lysosome inhibits phospholipase A2. It has recently been shown that antagonists of cytoplasmic phospholipase A2 inhibit multiple endocytic pathways 42. In this case, chloroquine could be maintaining BMPR-II at the cell surface via another mechanism other than lysosomal inhibition. Apr 23, 2018 a Accumulation of RIPK1 and RIPK3 in PC12 cells following treatment with lysosomal inhibitor chloroquine Chq, 100 μM. Cells were treated for 4 h. Cells were treated for 4 h. Chloroquine is a 9-aminoquinoline that has been known since 1934. Specifically synthesised to be used as an antimalarial agent, chloroquine was subsequently shown to have immunomodulatory properties that have encouraged its application in the treatment of autoimmune diseases such as rheumatoid arthritis.

    Take chloroquine for the entire length of time prescribed by your doctor. Continue taking the medicine regularly during your stay and for at least 8 weeks after you leave the area.

    Chloroquine lysosomal accumualtion

    In vitro autophagy modulation with chloroquine some lessons., Lysosomal damage after spinal cord injury causes accumulation.

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  7. Chloroquine CQ is a lysosomotropic agent with an extensive range of biological effects 1. Historically known for its anti-malarial activity, chloroquine is a widely used biological research tool for studying autophagy inhibition. Research studies demonstrate that chloroquine accumulates in acidic lysosomes and increases the lysosomal pH.

    • CST - Chloroquine.
    • Effects of chloroquine on viral infections an old drug..
    • Chloroquine - Wikipedia.

    Mar 08, 2011 Chloroquine is a known lysosomotropic agent that increases lysosomal pH by accumulating within lysosomes as a deprotonated weak base. To study the effects of lysosomal dysfunction in ARPE-19, it was necessary to establish an in vitro model utilizing chloroquine. Expression of the pfmdr1-encoded Pgh1 protein of Plasmodium falciparum in CHO cells confers a phenotype of increased sensitivity to chloroquine due to an increased Pgh1-mediated accumulation of this antimalarial. Pgh1 carrying amino acid substitutions associated with chloroquine resistance in P. falciparum does not confer this phenotype. Jan 27, 2010 Chloroquine CQ, traditionally used as an antimalarial medication, has emerged as a prospective adjunct in tumor therapy. CQ has been found to strongly potentiate the inhibitory effect of radiation on cancer cell proliferation, presumably via negative regulation of DNA repair processes.

     
  8. Kycoko User

    Plaquenil is the brand name for the prescription drug hydroxychloroquine. Plaquenil and Depression/Anxiety - Symptoms and Medical. Plaquenil - Uses, Side Effects, Interactions - Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis
     
  9. MAX-17 Well-Known Member

    Authors: Dr Anes Yang, Clinical Researcher, Department of Dermatology, St George Hospital, University of New South Wales, Sydney, NSW, Australia; Dr Monisha Gupta, Senior Staff Specialist, Department of Dermatology, Liverpool Hospital, Sydney, NSW, Australia. It is a hydroxylated version of chloroquine, with a similar mechanism of action. Hydroxychloroquine Plaquenil Hydroxychloroquine Side Effects Common, Severe, Long Term. Will you have Rashes with Plaquenil - eHealthMe
     
  10. alpenok XenForo Moderator

    Question about Plaquenil - Lyme Disease Hmm. I thought I posted already. Anyway, I was on Plaquenil for a long time with my LLMD. He liked it because it goes after Lyme and is an anti-inflammatory, so it helps you feel better. I don't know the exact research, but I'm pretty sure it is commonly used for Lyme

    Les antibiotiques remÈdes officiels face à lyme
     
  11. Safety of Immunosuppressive Drugs in Pregnant Women with. Among many non-biologic immunosuppressive drugs, hydroxychloroquine and cyclosporine are considered relatively ‘safe’ to use in pregnancy. Hydroxychloroquine can cross the placenta, but appears to have no effects on congenital defects, fetal death, or prematurity.7-9 Safety data on use of cyclosporine in pregnancy from transplant patients.

    Plaquenil Hydroxychloroquine - Side Effects, Dosage.