While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners. "I was on this hydroxychloroquine for 6 months and then suddenly developed severe itching (burning like sensation, worse than any itch I have ever had) and rash that went from my neck to my feet. Plaquenil and glutamate Novo chloroquine 250 mg What happens if you quit taking plaquenil Here is a short list Prednisone, Imuran, Remicade, Methotrexate Later sidesteps Prednisone's side effects, which include weight gain, mood swings, diabetes and eye problems, such as cataracts. I hope this was helpful enough. Has anyone experienced depression/severe mood swings from Plaquenil and/or prednisone? Emotionally, I am a different person than I was 2 months ago. Hydroxychloroquine is an antimalarial drug used to prevent and treat malaria. Hydroxychloroquine Plaquenil is also a disease-modifying anti-rheumatic drug DMARD used to treat both acute and chronic rheumatoid arthritis, systemic lupus erythematosus, and discoid lupus erythematosus. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Plaquenil is the brand name for the prescription drug hydroxychloroquine. Plaquenil mood swings Hydroxychloroquine User Reviews for Sjogren's. -, Has anyone experienced depression/severe mood swings from. Hydroxychloroquine sulfate tHydroxychloroquine water retentionHydroxychloroquine induced cardiomyopathy in systemic lupus erythematosusCan plaquenil cause eye problemsDrugs administered with chloroquine I am on my third day of 400mg of Plaquenil, and I am feeling pretty depressed for no apparent reason. Does anyone know if Plaquenil can cause depression or mood swings? Does it go away after you have been on it for a while? I am very new to all of this, so thanks for any advice! Plaquenil and mood swings? DailyStrength. Hydroxychloroquine Plaquenil Success, Reviews and Side Effects. My girlfriend has been taking plaquenil - HealthBoards. So glad you posted this and I now know I'm not the only one having the crazy reaction to Plaquenil. I have RA and was put on Plaquenil 1 week ago and noticed the extreme moods swings, frustration turning to extreme rage, feeling crazy, then crying over my reactions. Summary We study how severe was Mood swings, when it was recovered, drug effectiveness, race, and more among people who take Plaquenil. This study is created by eHealthMe based on reports of 1,993 people who have side effects when taking Plaquenil from sources other than FDA, and is updated regularly. View detailed reports from patients taking Hydroxychloroquine Sulfate who experienced mood swings. Reports are from official medical reports as well as online extractions from user reviews and forum discussions.