At first it seemed like it helped now I feel the same as before I started taking the medicine other than the fact that none of my clothes fit and there is a lot more of me to carry around. Anyone know if I quit taking it if the weight will fall back off I started Hydroxychloroquine 2 weeks ago. One week in and I thought this may just work, except for the ‘extra itchiness’ I seemed to get every night. Chloroquine cytotoxic hemozoin falicparum Hydroxychloroquine side effects fluid retention Serious side effects of plaquenil Re Plaquenil not working anymore Lizzy, I took 400mg 200 twice a day for 16-18 months forget exact duration, then was reduced to 200 mg daily. But right from the start, I also needed NSAID's for pain. And, smoking is not recommended for anyone, particularly those with a higher risk of cardiovascular disease. To prevent upset stomach, take Plaquenil with food. Also, the generic version of Plaquenil, hydroxychloroquine, can cause additional stomach irritation. If you are experiencing consistent stomach aches. Hi CatJ - I was also on that combination for 6 months but came off the Hydrox as it wasn't working for me and it also caused trouble with my eyes. However, that eventually settled down once not taking it any more. Had to see the eye surgeon at the hospital. No treatment required. Had spots on the corneas which the optician first noticed. I was prescribed this drug to ease my ra disease, I was taking 400mg per day which was to last for 3 months then reduced to 200mg. Right before I hit the two week mark, I woke up with my heart racing and continued feeling my heart flutter all day and I just felt week and tired. After msging Rheum, decided to stop taking meds to see how I feel and continue with the AIP to handle symptoms and try to work at ‘healing from inside out! Time will tell and I’m eager to see how much the AIP is helping once odd meds. Hydroxychloroquine not working Prednisone Not Working?" Rheumatoid Arthritis Community., Plaquenil Hydroxychloroquine for Lupus - LupusCorner Baseline testing for plaquenil Hydroxychloroquine experience improvement in their condition. Hydroxychloroquine does not work straight away. It may take 8 to 12 weeks for symptoms to start to improve. The full effect of treatment may take up to 26 weeks. Other medicines may be given to improve your symptoms while waiting for hydroxychloroquine to work. ATIENT NFORMATION ON HYDROXYCHLOROQUINE. Does anyone take methotrexate and hydroxychloroquine.. Hydroxychloroquine Oral Uses, Side Effects, Interactions.. Hydroxychloroquine does not work straight away. It may take 8 to 12 weeks for symptoms to start to improve. The full effect of treatment may take up to 26 weeks. Mar 24, 2011 Had headaches with the plaquenil so went to the sulfar and predisone. Sulfar was a waste of time and since I had a little help from the plaquenil he switched me back to that with pain meds for the headaches and body. Recently i went back for app. and plaquenil had stopped doing anything so he added the methotrexate to it. I did not want to take it. If Plaquenil doesn't work. Discussion in 'Medications' started by superloopie, Oct 22, 2009. superloopie Registered. I have been on the plaq since about June- 400 mg a day since early july. At first I was feeling much better, but that has changed. I have more and more fluid build up in my hands and wrists and the fatigue is strong again.