I did stop it for 2 weeks early in the treatment due to having to take a coupld other drugs that seemed to give me side effects. I just quit the plaquenil to give my liver a rest at that time. Plaquenil isn a antiparasitic drug with anti-inflammatory affect. Generic plaquenil gg 620 Hydroxychloroquine brands Plaquenil weight loss reviews IBS can cause cramping, bloating, gas, diarrhea, and constipation. IBS doesn’t damage the bowel or lead to other health problems. The doctor will diagnose IBS based on your symptoms. You may need to have medical tests to rule out other health problems. Stress doesn’t cause IBS, but it can make your symptoms worse. Normally, Plaquenil causes the opposite effect with diarrhea being the problem. I've not heard of anyone mentioning constipation as the side effect. That's not to say it doesn't happen though. I've been suffering from constipation for about a year. My constipation is mostly due to lack of moisture in the colon, not due to the hardness of my stool. Before testing positive for Antinuclear Antibodies Direct for Sjogren's Syndrome SS-B, I thought my constipation was perhaps due to my diabetes. Over the years on this site we have had quite a few people post that they didn't think that the plaquenil was working so they would stop taking it. I have done a lot of research on this drug and haven't run into anybody who has complained of the withdrawal effect. Plaquenil cause constipation Lactose Intolerance problems with Plaquenil? - Scleroderma., Bad Side Effects of Plaquenil - Molecular weight of chloroquine phosphateChloroquine depensed to us troop in honduranPlaquenil for arthritis According to Drugs.com, Plaquenil given for a long term can cause retinal disorders after a few months or years of daily use--especially if the dose exceeds 400mg per day. The risk of retinal damage increases at doses of 600mg to 700mg. Long-Term Side Effects of Plaquenil for Rheumatoid.. Constipation and Sjogren's Syndrome - HealthBoards. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. It seems like it took about 7 or 8 months for the Plaquenil 200mg 2x daily to.these medications including all of my cholesterol medications cause constipation so I follow a bowel regimen using sena and colace and sometimes MOM on bad nights and it works well for the most part. Re Prednisone, plaquenil and constipation. Thank you both for the replies, I just have to be so careful with my bowels since my surgery, and wanted to narrow down the possible root cause. Thank you so much. Plaq and some of my other meds say they cause stomach upset and diarrhea, but not gas. I am also on Keflex for sinus infection and strep throat, could it be the Keflex? I was wondering if since the plaq has reduced a lot of my pain, that I am taking much fewer narcotics which cause constipation, if that is why the plaq is now giving me the runs, gurgling stomach, GAS, GAS, GAS.