Chloroquine resistance in myanmar

Discussion in 'North West Pharmacy Canada' started by Serga1972, 07-Mar-2020.

  1. to4kaRU Moderator

    Chloroquine resistance in myanmar

    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Areas with drug resistant Malaria The states of Bago, Kayah, Kachin, Kayin, Shan, and Tanintharyi eastern half of the country, including the areas bordering China, Laos, and Thailand report P. falciparum malaria resistance to chloroquine, mefloquine hydrochloride and sulfadoxine-pyrimethamine. Resistance to artemisinin is reported from. The porous border with Myanmar could be one of the major entry routes of drug-resistant parasites to mainland India. In 1973, the first cases of P. falciparum chloroquine resistance CQR were reported from Karbi Anglong district in Assam 5. In the early 1980s, CQR was reported in Mizoram 6. In Myanmar, high-level resistance to chloroquine and pyrimethamine–sulfadoxine was reported more than a decade ago 11 – 13. Our molecular survey showed that the major chloroquine resistance allele CVIET has reached fixation, and triple and quadruple mutations in pfdhfr and pfdhps were highly prevalent in this region.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine resistance in myanmar

    Emergence of chloroquine-resistant Plasmodium vivax in., Epidemiology of malaria and chloroquine resistance in Mizoram.

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  5. All the chloroquine-resistant cases were again treated with chloroquine 1500 mg and no further recrudescence or relapse was detected on days 21 and 28. This study indicates that chloroquine is losing its efficacy against P. vivax in Myanmar. Malaria, Plasmodium vivax, chloroquine resistance, Myanmar

    • Development of resistance to chloroquine by Plasmodium vivax..
    • Multidrug-Resistant Genotypes of Plasmodium falciparum, Myanmar.

    South East Asia has been implicated in the rise of resistance to both chloroquine and artemisinin. The main explanation is that lower levels of natural malaria immunity exist in the region than in Africa. With no background resistance, the drugs have to do all the work in infected patients in South East Asia. Malaria. Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. ovale, and P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Chloroquine has been extensively used in mass drug administrations. Plasmodium vivax malaria remains a major public health burden in Myanmar. Resistance to chloroquine CQ, the first-line treatment for P. vivax, has been reported in the country and has potential to undermine local control efforts.

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