I was diagnosed with discoid lupus 18 years ago and was prescribed Plaquenil, which I have taken since then. In October 2012, I was also diagnosed with Sjogrens Syndrome but, as I was already taking Plaquenil, was advised the treatment was the same for Sjogrens. Chloroquine action Malarone chloroquine resistance Hydroxychloroquine sun pharmaceuticals White blood cell count decreased is found among people who take Plaquenil, especially for people who are female, 60+ old, have been taking the drug for 1 month, also take medication Enbrel, and have High blood pressure I gradually increased from 50 to 100 to 200mg. Include eating dark leafy greens cooked every week to MAINTAIN vision. Still continuing and I hope it suppresses my immune system so that I can "slow down" and increase WBC. During 1997 I was checked by an MD and was told I could get SLE, SS, RA from having low WBC. F 60 200 1X D 3/20/2016 1 Aug 14, 2017 According to the New Zealand Dermatological Society, Plaquenil can cause abnormalities in blood counts. An abnormally low number of white blood cells can lead to infection, because white blood cells defend the body against bacteria. Low platelet count thrombocytopenia can lead to easy bleeding and bruising. From research I have done online, I gather that low white cell count can also be a symptom of the Sjogrens in itself. At a recent medical with my doctor, blood tests were taken and I had a call a couple of days later telling me to stop taking g Plaquenil immediately as I have a very low white cell count and that it is sometimes a side effect of Plaquenil. Hydroxychloroquine cause low wbc Hydroxychloroquine - Side Effects, Dosage, Interactions., HYDROXYCHLOROQUINE SULFATE Side Effects, Reviews by Patients. Plaquenil for throat inflammationPlaquenil homeopathy Low white cells are a part of the autoimmune issue. This is something that I have dealt with for years. I have been on the Plaquenil a couple of years now and my immunologist told me that Plaquenil doesn't cause the same issues as the DMARDS or the methotrexates, imuran, etc. Link between low white cell count and taking Plaquenil?. Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis.. Hydroxychloroquine - Wikipedia. Summary White blood cell count decreased is found among people who take Plaquenil, especially for people who are female, 60+ old, have been taking the drug for 1 month, also take medication Enbrel, and have High blood pressure. Yes, Plaquenil can cause aplastic anemia, agranulocytosis, leukopenia, anemia, thrombocytopenia. So yes, this could be the cause of your WBC count going down, and for anemia that you have. Apart from that it can also be due to anti-thyroid cancer drugs. Please discuss with your doctor, and see if some other drugs can be started for you. Take care! Blood tests If you take this medication for a long period of time, your doctor will likely want you to have blood tests to monitor your levels of red and white blood cells. Blood sugar levels Hydroxychloroquine may cause hypoglycemia low blood sugar levels. People with diabetes may find it necessary to monitor their blood sugar more.