All my issues were resolved over a years time on low doses. I believe my problems started with side effects of a statin, which I stopped taking during my Plaquenil treatment but resumed after symptoms were resolved. Chloroquine autophagy inducer Why would you take hydroxychloroquine and mycophenolate Treatment should be discontinued if hydroxychloroquine treatment is identified as the cause of any of these serious blood dyscrasias 2. Neurological and Neuromuscular Reactions. In New Zealand, there have been two reports of peripheral neuropathy associated with hydroxychloroquine use since 1 January 2010. I used Plaquenil years ago for extreme muscle and joint issues and it seemed to work fine. All my issues were resolved over a years time on low doses. I believe my problems started with side effects of a statin, which I stopped taking during my Plaquenil treatment but resumed after symptoms were resolved. Because of the limited experience with chloroquine or hydroxychloroquine in treating sarcoidosis, only vague clinical guidelines exist regarding the dose, duration of treatment, and need and means for monitoring drug toxic effects. In earlier years of this study, I used chloroquine phosphate, 250 mg twice daily. Has anyone had neurological issues resolved with a Plaquenil treatment? I used Plaquenil years ago for extreme muscle and joint issues and it seemed to work fine. Years later I am now having small fiber issues in my hands which I think were triggered by side effect of statins and am looking for solutions. Hydroxychloroquine causing neuropathy Hydroxychloroquine Indications, Side Effects, Warnings., Plaquenil and small fiber neuropathy - NeuroTalk Support. Plaquenil classificationChloroquine and primaquine treatment Druginformer Identified Side Effects Neuropathy peripheral, Muscle atrophy, Muscle twitching. Posted By Anonymous in on August 26, 2005 @ am “ Side Effects Twitching, muscle loss, peripheral neuropathy symptoms. My rheumatologist said that he hasn't ever seen a worse reaction to this drug. Hydroxychloroquine Sulfate Neuropathy Peripheral Reports - DrugInformer. Effectiveness of Chloroquine and Hydroxychloroquine in.. Hydroxychloroquine-Induced Toxic Myopathy Causing.. Peripheral neuropathy is found among people who take drugs with ingredients of hydroxychloroquine sulfate, especially for people who are female, 60+ old also take medication Methotrexate, and have High blood pressure. Antimalarials are used in the treatment of dermatologic, rheumatic, and connective tissue diseases.1Chloroquine CQ toxicity is known to cause vacuolar myopathy and curvilinear body formation.2Hydroxychloroquine HCQ neuromyotoxicity is a rare complication characterized by proximal muscle weakness. Hydroxychloroquine induced myopathy is rare adverse reaction but symptoms are usually recover after discontinuation of the drug. Here we report a case of woman with systemic lupus erythematosus who presented with myopathy after eight months treatment with hydroxychloroquine. Her symptoms were recovered after cessation of the drug.