Hydroxychloroquine overdose toxicokinetics and management

Discussion in 'North West Pharmacy Canada' started by trylogy, 08-Mar-2020.

  1. bolshas XenForo Moderator

    Hydroxychloroquine overdose toxicokinetics and management

    One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus.

    Chloroquine for malaria in pregnancy Mycophenolate and plaquenil for dermatomyositis

    Although hydroxychloroquine overdoses are very rare, life-threatening hypotension, conduction problems, and hypokalemia can occur within 30 minutes of ingestion. Symptoms are similar to chloroquine and treatment must be implemented quickly and should be modeled after experience with chloroquine overdoses. Hydroxychloroquine overdose is infrequently reported and the majority of recommendations come from the greater experience with chloroquine poisoning. We report two cases of massive hydroxychloroquine poisoning 20 g in each case, both of which received advanced cardiac life support and a treatment regimen consisting of sodium bicarbonate, adrenaline and potassium. Chloroquine and hydroxychloroquine belong to the quinolone family. They are related drugs with similar clinical indications for use and similar manifestations of retinal toxicity, although their therapeutic and toxic doses differ.

    It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress.

    Hydroxychloroquine overdose toxicokinetics and management

    Massive hydroxychloroquine overdose Request PDF, Survival after Massive Hydroxychloroquine Overdose - N. Gunja.

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  5. Quick treatment of hypotension, gastric decontamination, continuous long-term cardiac monitoring, and treatment of arrhythmias are the cornerstones of hydroxychloroquine overdose management.

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    Hydroxychloroquine Plaquenil is an aminoquinoline derivative, closely related to chloroquine, that is used in the treatment of malaria, lupus erythematosus and rheumatoid arthritis. It is available as the sulfate salt Hydroxychloroquine – which has a similar toxicity profile – has largely superseded it for the treatment of rheumatoid arthritis. In overdose both chloroquine and hydroxychloroquine cause sodium channel blockade with primarily cardiovascular and central nervous system effects, as well as hypokalemia due to intracellular potassium shifts. Hydroxychloroquine is a 4-aminoquinoline derivative prepared by beta hydroxylation of chloroquine. It is used in the treatment of malaria, rheumatoid arthritis, and lupus erythematosus, and marketed under the name Plaquenil Sanofi Pharmaceuticals, New York, NY.

  6. softloki Well-Known Member

    Lupus fog -- the forgetfulness and fuzzy-headed feeling that can come with lupus (systemic lupus erythematosus, or SLE) – can be one of the most frustrating symptoms of the condition. Positive SSB negative SSA-- no dry eyes or mouth Lupus? RA? Sjogren’s? Do I need a second opinion? - Lupus. Plaquenil and Brain Fog / Memory Issues / Anti RNP.
  7. Hydroxychloroquine is used to prevent or treat malaria infections caused by mosquito bites. Plaquenil - FDA prescribing information, side effects and uses Drugs & Medications - WebMD Plaquenil Dosage Guide -
  8. merlja Moderator

    PLAQUENIL HYDROXYCHLOROQUINE SULFATE TABLETS, USP DESCRIPTION PLAQUENIL hydroxychloroquine sulfate tablets contain 200 mg hydroxychloroquine sulfate, equivalent to 155 mg administration. Inactive Ingredients. PLAQUENIL is indicated for the prophylaxis of malaria in geographic areas where chloroquine resistance is not reported.

    PLAKVENIL - Instrukcje użytkowania, Opis leki. P
  9. Vlad_dd Moderator

    THE SIXTH MEETING OF THE GREATER MEKONG SUBREGION GMS. The Sixth Meeting of the Greater Mekong Subregion GMS Therapeutic Efficacy Studies TES Network was convened in Luang Prabang, Lao People’s Democratic Republic, from 27 to 28 September 2018. rganized by the WHO O egional offices for Southr East Asia and - the Western

    Drug Resistance in the Malaria-Endemic World - CDC