Plaquenil and radiation therapy toxiciy

Discussion in 'Pharmacy Northwest Canada' started by Stusa, 16-Mar-2020.

  1. 64RIK Moderator

    Plaquenil and radiation therapy toxiciy


    Managing cancer in patients with concomitant rheumatoid arthritis poses special challenges that require close coordination of care between oncologists and rheumatologists. Immune-related adverse events with use of checkpoint inhibitors for immunotherapy of cancer. Potential clinical issues needing special consideration include: 1) perioperative management in patients undergoing cancer surgery, which often requires discontinuation of antirrheumatic therapy; 2) use of immunosuppressant therapies for rheumatoid arthritis, especially biologic agents that inhibit cytokine and immune pathways, which conceivably could affect immune-mediated antitumor responses (the issues are different in patients with active cancer vs those with a past history of cancer and no recurrences); 3) management in the palliative care setting; and 4) use of cancer immunotherapy, such as checkpoint inhibitor agents, in patients with pre-existing rheumatoid arthritis.

    Hydroxychloroquine gh 200 mg Chloroquine et grossesse

    Systemic Lupus Erythematosus, Radiotherapy, and the Risk of Acute and Chronic Toxicity The Mayo Clinic Experience. The subjects were chosen by cross-reference of a comprehensive list of patients treated with any form of radiation therapy at the Mayo Clinic Department of Radiation Oncology, by using an electronic record search of the master. The patient would like to undergo lumpectomy followed by radiation therapy but is concerned about the possible adverse effects of radiotherapy in women with rheumatoid arthritis. A few studies have evaluated the risk of radiation therapy in patients with cancer and connective tissue diseases, especially scleroderma and lupus erythematosus. Very rare presentation of hydroxychloroquine toxicity. CASE PRESENTATION 36 year old female presented with fever, malaise, chills and a lip rash for 3 days past history included eosinophilic fasciitis being treated with methotrexate for 2 years which was stopped due to intolerence 3 weeks ago and she was started on hydroxychloroquine 300mg daily. Investigation revealed WBC 300.

    In all cases, clinical decision making must include a careful weighing of risks and benefits of both cancer treatments and antirrheumatic therapies, with attention given to prognosis and life expectancy, quality of life, and patient preferences. TNF inhibitor therapy and risk of breast cancer recurrence in patients with rheumatoid arthritis: a nationwide cohort study. We explore these clinical issues in case-based scenarios.

    Plaquenil and radiation therapy toxiciy

    Of Cancer Treatment Dental Provider’s Oncology, Management Considerations in Cancer Patients With.

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  6. A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme

    • PDF A PHASE I/II TRIAL OF HYDROXYCHLOROQUINE IN CONJUNCTION..
    • Hydroxychloroquine induced profound neutropenia with s..
    • Radiation Therapy and Tamoxifen Concurrent or Sequential..

    RATIONALE Drugs used in chemotherapy, such as hydroxychloroquine and temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill tumor cells. Hydroxychloroquine HCQ trade name, Plaquenil and chloroquine CQ trade name, Aralen are drugs established in the treatment of autoimmune disease and skin disorders, but are also emerging as a. Hydroxychloroquine and chloroquine are antimalarial drugs commonly used for the treatment of rheumatic diseases. Multiple mechanisms might explain the efficacy and adverse effects of these drugs.

     
  7. hot XenForo Moderator

    Chloroquine is the generic form of the brand-name prescription medicine Aralen, which is used to prevent and treat malaria — a mosquito-borne disease caused by a parasite — and to treat amebiasis, an infection of the intestines caused by a parasite. Chloroquine Oral Uses, Side Effects, Interactions. Chloroquine Dosage Guide with Precautions - Chloroquine - LiverTox - NCBI Bookshelf
     
  8. RuB Well-Known Member

    Hair loss w/ plaquenil temporary adjustment or permanent? I read that hair loss can be a side effect but the literature on RX from CVS says that's a "more serious" side effect and I should contact my doctor. However, it seems like there are a lot of posts on here and elsewhere about people losing hair because of Plaquenil.

    Hair loss in Plaquenil how severe and when it was.
     
  9. cray Well-Known Member

    Protecting your eyesight when taking Plaquenil Lupus. For women, start with 100 pounds, and add 5 pounds for every inch over 5 feet. For men, start with 106 pounds, and add 6 pounds for every inch over 5 feet. The maximum dose of Plaquenil is 6.5 mg/kg of ideal body weight per day, regardless of whether a person is overweight, underweight, or normal weight.

    Stopping Plaquenil - General Discussion - Life With Lupus