One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Hydroxychloroquine plaquenil motrin Retinal toxicity plaquenil Chloroquine exocytosis Twenty-seven percent of cases of hydroxychloroquine retinopathy in obese women had ostensibly safe dosing based on 2016 AAO guidelines. Overdosing of obese women by 2016 AAO guidelines is not rare. Daily dosing based on the older 6.5-mg/kg ideal weight threshold is safer in women with a body mass index of 30 kg/m 2 or more. Medscape - Indication-specific dosing for Plaquenil hydroxychloroquine sulfate, frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. The 2011 AAO guidelines recommended dosing hydroxychloroquine based on ideal body weight – what a patient should weigh for their height. This was supposed to ensure that people who were very short or overweight got the right amount of drug. The proposed daily dose was 6.5 mg per kg of ideal body weight. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Aao plaquenil dosing Recommendations on Screening for Chloroquine and., Plaquenil hydroxychloroquine sulfate dosing, indications. Chloroquine and malaria Doses ≥ 5 mg/kg/day real weight of hydroxychloroquine 2.3 mg/kg/day of chloroquine are associated with higher risk of toxicity. Doses lower than 5 mg/kg/day have low risk 1% for the first 5 years, and below 2% between 5-10 years of use. The longer you use the medication, the higher the risk of toxicity. Hydroxychloroquine And Chloroquine Screening 2016 AAO.. Wrong Hydroxychloroquine Dose Is Common, Putting Eyes at.. New App to Tackle Hydroxychloroquine Dosing Dilemma.. Differential diagnosis – juxtafoveal telangiectasia – FFA to rule out In a confirmed case of tamoxifen toxicity with visual complaints, the drug must be stopped. Since maculopathy is rare, routine screening is not needed with current low dose therapy 10-20mg/day. Rosenbaum discussed the guidelines from the American Academy of Ophthalmology AAO published in Ophthalmology. He reviewed the data which supports the use of the guidelines daily dose 5 mg/kg of actual body weight; a baseline eye exam; and eye exams at 5 years and annually thereafter. Dosing. Hydroxychloroquine is generally prescribed at a daily dose of 6.5 milligrams or less per kilogram of body weight. Using this formula, the dosage for a 150-pound person would be 443 mg/day, as one kilogram equals 2.2 pounds. Because HCQ is formulated as a 200 mg tablet, many people taking it for lupus will take two pills per day.