One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Chloroquine allergy What will happen if i stop taking plaquenil Plaquenil and coq10 What is the drug plaquenil used to treat Several reports previously described abnormal OCT findings, including parafoveal thinning and abnormalities in the parafoveal photoreceptor inner segment/outer segment junction in patients with chloroquine or hydroxychloroquine retinal toxicity. However, those patients with noticeable OCT changes had clinical symptoms, visual loss, visual field defects, colour vision deficiency, or abnormal mfERG findings. Early macular toxicity can cause stippling or mottling of the RPE Next, granular pigmentation and loss of the normal foveal reflex can occur It’s believed but not proven that if early macular changes are detected and the medication is stopped, any toxicity that has occurred can be reversed.1 Early detection of the maculopathy is of critical importance to discontinue Plaquenil in order to stop or slow retinal damage. Unfortunately, clinically evident early structural changes can be subtle and usually preceded by abnormalities in functional tests such as visual field examination, multifocal electroretinography mfERG, fundus autofluorescence FA imaging, and optical coherence tomography. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Early oct changes plaquenil How to Succeed in Plaquenil Screenings, Early Plaquenil Toxicity Detected without Bull’s Eye. Plaquenil weight gain loss Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Plaquenil Side Effects Common, Severe, Long Term -. The Risk of Retinal Toxicity with Plaquenil. New Plaquenil Guidelines. In Hydroxychloroquine Retinopathy. whether hsUHR-OCT could show distinctive structural changes that might occur before patients lose vision or. ultra–high-resolution optical coherence tomography allows for detailed visualization of the retinal structure on the level of individual retinal layers. Today it is recommended that every single person on Plaquenil get a visual field 10-2 test, plus one of the three other highly sensitive screening tests the FAF fundus autofluorescence imaging, the SD-OCT spectral domain optical coherence, or the multifocal electroretinogram mfERG,” Thomas says. Although there were many cases with both early field loss and early SD-OCT damage, there were no cases in our population with prominent parafoveal anatomic damage and no field changes at all. Figure 3 shows a case with distinct parafoveal thinning, but field losses that are spotty and might be dismissed as normal or at least left for later confirmation.