Ocular safety of hydroxychloroquine

Discussion in 'Trusted Online Pharmacy' started by BUROZERMEDO, 05-Mar-2020.

  1. NeoSky Well-Known Member

    Ocular safety of hydroxychloroquine


    Plaquenil is less toxic than chloroquine; however, long-term use of either drug can result in macular toxicity, leading to devastating irreversible vision loss. The mechanism of this toxicity is not clearly understood, though it is believed that the drug molecule binds to melanin in the retinal pigment epithelium (RPE).

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    In summary, hydroxychloroquine-induced retinal toxicity is likely more prevalent than previously believed. Once thought to be safe at a daily dose of 6.5mg/kg/day 16, newer studies show that many years of hydroxychloroquine treatment at a "safe dose" can still lead to toxicity 6. Newer guidelines state that daily dose 5mg/kg of real. Ocular manifestations of hydroxychloroquine include corneal verticillata and retinal toxicity. Verticillata are cornea deposits of salts within the corneal epithelium. This condition does not cause symptoms and is reversible with cessation of the medication. More importantly, it has repositioned hydroxychloroquine from one of the safest medications that rheumatologists use to a drug that can have potentially significant ocular morbidity if used in doses greater than 5 mg per kilogram and or for prolonged periods of time.

    Binding of the drug to melanin in the RPE contributes to, or prolongs, its toxic effects. This leads to disruption and damage to the photoreceptors and outer nuclear and plexiform layer, sparing the foveal center and resulting in the “bull’s eye” appearance in the late stage of the disease.

    Ocular safety of hydroxychloroquine

    The ocular safety of hydroxychloroquine - ScienceDirect, Hydroxychloroquine Plaquenil Toxicity and.

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  5. Hydroxychloroquine Plaquenil is used to treat malaria, lupus, and rheumatoid arthritis. Learn about side effects, warnings, dosage, and more.

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    On examination, a telltale sign of hydroxychloroquine toxicity is a bilateral change in the retinal pigment epithelium of the macula that gives the commonly described appearance of a bull’s-eye. This is a late finding, however, and too late for screening to be useful. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. The AAO published dosing and screening recommendations for chloroquine and hydroxychloroquine in 2016, revising previous recommendations published in 2011. The current maximum daily HCQ dose recommended by the AAO is 5 mg/kg of real weight. The 2011 guidelines suggested a maximum dose of 6.5 mg/kg of ideal weight.

     
  6. GGC Manager New Member

    Hydroxychloroquine (Plaquenil) is considered a disease-modifying anti-rheumatic drug (DMARD). Plaquenil Hydroxychloroquine Side effects, Images, Uses. Protecting your eyesight when taking Plaquenil Lupus. Plaquenil Dosage Guide -
     
  7. 3adira User

    Will you have High blood pressure with Plaquenil - eHealthMe Summary High blood pressure is found among people who take Plaquenil, especially for people who are female, 60+ old, have been taking the drug for 1 month, also take medication Enbrel, and have Pain.

    Medications and supplements that can raise your blood.
     
  8. Akopyan Moderator

    Plaquenil From Malaria Treatment to Managing Lupus, RA - The. May 15, 2015 Plaquenil From Malaria Treatment to Managing Lupus, RA. Plaquenil is a mainstay of treatment for inflammatory arthritis and skin symptoms. In 1984, I wrote my first prescription for the antimalarial drug, hydroxychloroquine Plaquenil, for a 28-year-old woman with SLE.

    PLAQUENIL" Rheumatoid Arthritis Community - Support Group