Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. Plaquenil severe rash Eye effects of plaquenil Cr3 ii chloroquine Visual field tests abnormal is found among people who take Plaquenil, especially for people who are female, 60+ old, also take medication Amlodipine, and have Asthma Aug 20, 2015 Screening for hydroxychloroquine retinopathy is dependent on ancillary testing as the clinical examination is insensitive and nonspecific for retinopathy.1 Since the early 1990s, the 10–2 visual field VF has been the most commonly used ancillary test.2–4 Multifocal electroretinography mfERG, spectral domain optical coherence tomography SD-OCT, and fundus autofluorescence FAF have been introduced more recently, and gained wider acceptance when advocated in the revised guidelines. Paracentral scotomas have been reported prior to the associated maculopathy, so an amsler grid test or central 10-2 visual field perimetry was recommended. 2,5. Additionally, color vision––helping in the assessment of macular integrity––was recommended as an optional test. Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Plaquenil and visual field testing MEDICAL POLICY Visual Field Examination, Scotoma analysis of 10–2 visual field testing with a red. Side effects of chloroquine on eyePlaquenil behcet'sChloroquine phosphate for malariaHydroxychloroquine copay assistance program Feb 19, 2020 In patients of Asian descent, it is recommended that visual field testing be performed in the central 24 degrees instead of the central 10 degrees. It is recommended that hydroxychloroquine be discontinued if ocular toxicity is suspected and the patient should be closely observed given that retinal changes and visual disturbances may progress. Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects.. New Plaquenil Guidelines. Visual Field Test Learn How the Procedure Is Performed. In early cases of Plaquenil toxicity, an early indicator of damage is the appearance of a paracentral scotoma seen on automated visual field testing in the absence of fundus changes. 18 Each of the testing strategies can be used to detect early toxicity changes, but the presentation of the visual field effects will vary. Due to the central area being depressed in the 24-2 and 30-2 testing strategies, it is difficult to discern the central 2-degree field of sparing seen in the 10-2 tests. In patients of Asian descent, it is recommended that visual field testing be performed in the central 24 degrees instead of the central 10 degrees. It is recommended that hydroxychloroquine be discontinued if ocular toxicity is suspected and the patient should be closely observed given that retinal changes and visual disturbances may progress even after cessation of therapy. The main outcomes were toxicity as determined by characteristic visual field loss or retinal thinning and photoreceptor damage. They also examined risk factors and prevalence. The study findings revealed that when hydroxychloroquine was used at doses 5mg /kg, the risk of retinopathy was 1% in the first 5 yrs. 2% in 10 yrs. 20 % after 20 yrs.