This dose should not exceed 6.5 mg/kg/day (calculated from ideal body weight and not actual body weight) and will be either 200 mg or 400 mg per day. In patients able to receive 400 mg daily: Initially 400 mg daily in divided doses. Plaquenil and osteoarthritis Chloroquine against malaria Hydroxychloroquine also known as Chloroquine clathrin Adult doses range from 400 mg/week for suppressive therapy to 1,200 mg/day for acute malaria attacks. Typical daily doses of 200 to 600 mg are used for lupus and rheumatoid diseases. Hydroxychloroquine has a long terminal elimination half-life in blood 40 days, which exceed those in plasma. The oral bioavailability averages 79%. Drug Half Life Calculator This is a simple Half life calculator that computes the concentration of a drug in the body based on your dosage and the known half life of your medication. You can find the half life of any medications you're using by checking the medication guides on this website. The absorption half-life was approximately 3 to 4 hours and the terminal half-life ranged from 40 to 50 days. The long half-life can be attributed to extensive tissue uptake rather than through decreased excretion. Peak plasma levels of hydroxychloroquine were seen in about 3 to 4 hours. The maintenance dose should be increased to 400 mg daily if the response lessens. The dose can be reduced to 200 mg when no further improvement is evident. Plaquenil elimination half life Let me tell you what weaning down from Plaquenil is like., Drug Half Life Calculator - Antimalarial plaquenilPlaquenil and weight loss OverviewMedical useAdverse effectsInteractionsOverdosePharmacology Hydroxychloroquine - Wikipedia. Plaquenil - FDA prescribing information, side effects and uses. Bioavailability of hydroxychloroquine tablets in healthy.. Provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex updated, Cerner Multum™ updated, The mean time to peak plasma concentration was 1.83 hours. The mean plasma elimination half-life varied, depending on the post-administration period, as follows 5.9 hours at C max-10 hours, 26.1 hours at 10-48 hours and 299 hours at 48-504 hours. The parent compound and metabolites are widely distributed in the body and elimination is. With a half-life of 537 hours 22.4 days. In the same study, the plasma peak concentration was. 50.3 ng/mL reached in 3.74 hours with a half-life of 2963 hours 123.5 days. Urine hydroxychloroquine levels were still detectable after 3 months with approximately 10% of the dose excreted as the parent drug.