Many yeast infection treatments come in 1-day, 3-day, and 7-day strengths. Over-the-counter vaginal creams and other products you can buy often have the same ingredients to fight a yeast infection as the medication your doctor might prescribe, but in less-concentrated doses. Vaginal creams go inside the vagina to kill off the yeast that cause yeast infections. Sometimes called antifungal creams, these products usually come with an applicator that measure the right dose. Common medicines are: Vaginal creams can be messy and may leak out during the day, so you’ll only want to use them at bedtime. Some of these products may come with a cream that you put on the opening of the vagina and surrounding tissue (called the "vulva") and not into the vagina. This type of cream may ease itching and treat the skin tissues while the vaginal antifungal cream treats the yeast infection. 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