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    The removal of cannabis from Schedule I of the Controlled Substances Act, the most tightly restricted category reserved for drugs that have "no currently accepted medical use," has been proposed repeatedly since 1972. Rescheduling proponents argue that cannabis does not meet the Controlled Substances Act's strict criteria for placement in Schedule I and so the government is required by law to permit medical use or to remove the drug from federal control altogether. The US government, on the other hand, maintains that cannabis is dangerous enough to merit Schedule I status. The dispute is based on differing views on both how the Act should be interpreted and what kinds of scientific evidence are most relevant to the rescheduling decision. The Act provides a process for rescheduling controlled substances by petitioning the Drug Enforcement Administration. The first petition under this process was filed in 1972 to allow cannabis to be legally prescribed by physicians. The petition was ultimately denied after 22 years of court challenges, but a synthetic pill form of cannabis's psychoactive ingredient, THC, was rescheduled in 1986 to allow prescription under schedule II. Imitrex is classified as a triptan drug, and its chemical structure is similar to serotonin. Migraine pain is thought to be caused by dilation of the cerebral arteries. Triptans activate receptors in the brain to counter this process, causing vasoconstriction, a narrowing of the blood vessels. Imitrex is normally administered orally, in 25, 50, or 100 mg tablets, though it is also available as an injection and a nasal spray. The dosage varies based on the frequency and severity of migraine pain, but no one should take more than 200 mg in a 24-hour period. Controlled clinical trials have suggested that doses higher than 50 mg aren't significantly more effective at relieving pain, anyway. Imitrex is most effective when taken before the migraine fully begins or as soon as possible after the onset of pain.

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